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BBR 2778 was more cytotoxic in leukemia and lymphoma cell lines than in solid tumor cell lines. Although against in vivo models BBR 2778 was less potent than mitoxantrone and doxorubicin, its antitumor activity was equal or superior (in certain tumor models) to that of the above standard compounds.

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Ubiali F, et al. Pixantrone (BBR2778) reduces the severity of experimental autoimmune myasthenia gravis in Lewis rats. Original article Phase I study of BBR 2778, a new aza-anthracenedione, in advanced or refractory non-Hodgkin’s lymphoma P. Borchmann, 1 R. Schnell, 1 R. Knippertz, 1 J.O. Staak, 1 G.M. Camboni, 2 A. Bernareggi, 2 K. Hübel, 1 P. Staib, 1 A. Schulz, 1 V. Diehl, 1 A. Engert, 1 [email protected] de 1 Klinik I für Innere Medizin der Universität Köln, Köln, Germany Klinik I BBR 2778 (6,9 [bis (2-aminoethyl)-amino]-benzo [g] isoquinolone-5,10-dione dimaleate salt) is a novel heteroanalogue of anthracenediones ().The mechanism of action of BBR 2778 is similar to that of mitoxantrone in terms of DNA intercalation, DNA affinity, topoisomerase II interaction and formation of single strand breaks. BBR 2778. A substance that is being studied in the treatment of cancer.

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2016-10-18

• Feb 26, 2020. 24. 2.

av M Virefjäll · Citerat av 1 — naden når upp till BBR:s grundläggande krav för nybyggnad.13 som precis klarar de lägsta kraven enligt BBR. 0,100/0,036 = 2,778.

Keywords:BBR-2778, cardiotoxicity, non-Hodgkin, lymphoma, pixantrone, Pixuvri ®. Abstract:This review will trace the steps in the development of pixantrone dimaleate (initial code BBR 2778, Pixruvi ®), an anthracenedione chemotype, as a chemotherapeutic agent. Rank Web of Science journal category Relevance score (tfidf) Class's shr. of term's tot.

Cavalletti E, et al. Pixantrone (BBR 2778) has reduced cardiotoxic potential in mice pretreated with doxorubicin: comparative studies against doxorubicin and mitoxantrone. Invest New Drugs. 2007 Jun;25(3):187-95.
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BBR 2778 was more cytotoxic in leukemia and lymphoma cell lines than in solid tumor cell lines. Although against in vivo models BBR 2778 was less potent than mitoxantrone and doxorubicin, its antitumor activity was equal or superior (in certain tumor models) to …

0,175. 0,14. flag 516 BBR 69 · flag 52-77-KL · flag 5222 RM 73 · flag 5234 WG 06 · flag flag GE 299940 · flag GE 299958 · flag GI-2778-AS · flag GI-DT 150 · flag GL HF 67. AIC, 54501. AKRON-MALÒ, TER463. ASAM, 73301.